Endocrine Abstracts

Cushing’s disease (CD) results in chronic exposure to increased levels of cortisol leading to alterations in white matter microarchitecture and adverse effects on cognitive functioning. Diffusion tensor imaging (DTI) is a novel technique used to evaluate the integrity of white matter (WM) architecture. There is little information on DTI changes in CD. We studied WM changes in CD using diffusion tensor imaging and compared with healthy controls. 16 patients with active CD ...

Aim: Indications for Radioiodine (131I) in therapy for benign thyroid disease include Graves’ disease, Toxic goitre and euthyroid goitre. There is reduced clinical & financial implication as compared to surgery with absence of anaesthetic/invasive complications, pain, recovery and in-patient stay. The aim of this study was establishing demographics and prevalence of the treatment population, to ensure dosage and indication compliance with national guidelines as well a...

Introduction: The aim of the present study was to evaluate the glycaemic control, antioxidant, pancreas and liver protective effect of 2β-hydroxybetulinic acid 3β-caprylate (HBAC) from Euryale ferox Salisb. seeds on streptozotocin induced diabetic rats.Materials & methods: The active principle was isolated from Euryale ferox Salisb. seeds extract by utilizing chromatographic techniques. The rats were divided into seven exp...

Background: The hypothalamic–pituitary–adrenal axis has a pivotal role in combating acute insults. Glucocorticoids play a role directly or indirectly in the maintenance of normal vascular tone and in potentiating the vasoconstrictor action of catecholamine, associated with septic shock.Aims: To determine the incidence of adrenal insufficiency (AI) and its relation to mortality in patients with septic shock.Settings and de...

The number of the people with type 2 diabetes is increasing globally, therefore there is an increasing need to identify diabetes earlier and more efficiently. Nearly 80% of people with diabetes live in low and middle income countries (LMICs). Traditionally, we have relied on glucose-based criteria (fasting, postprandial, and random) to make the diagnosis of diabetes; however, HbA1c has recently been endorsed as a diagnostic test, as superior alternative to glucose-based criter...

Background: Diabetic ketoacidosis is characterised by biochemical tired of hyperglycemia, acidosis, and ketonemia. It remains a life threatening condition despite improvement in diabetic care, timely identification and intervention remains the backbone of treatment.Aim and objectives: i) To evaluate the clinical and biochemical prognostic markers in diabetic ketoacidosis. ii) To correlate the various prognostic markers with mortality in diabetic ketoacid...

Background: The metabolic syndrome is one of the fastest growing epidemics of the modern era in both the industrialised as well as developing world. Waist circumference (WC) is an important component to diagnose metabolic syndrome. Cut off point of WC to diagnose metabolic syndrome is different in.different ethnic groups.Objective: To study and correlate the variation in prevalence of metabolic syndrome depending on the site of waist measurement and to s...

Background: Sheehan’s syndrome or postpartum pituitary necrosis though rare, is still remains one of the commonest causes of hypopituitarism in the developing parts of world like Indian subcontinent. The clinical presentation is often variable and frequently accompanied by hypogonadism which leads to low bone density due to loss of bone protective effect of oestrogen.Aims: To find out the bone mineral density and the quality of life (QoL) i...

Type 2 diabetes with poor glycemic control is a predisposing factor for periodontitis (Salvi et al. 2000). In this cross sectional study, subjects with type 2 diabetes (n=232, mean age: 50.08±3.2 years) were recruited with informed and written consent. Fasting plasma glucose, serum lipid profile and HbA1c was analysed by standardised methods. A complete dental examination for pocket depth, clinical attachment level and periodontitis was performed for all...

Objective: To determine effectiveness of supplementing vitamin D alone vs vitamin D+ calcium on bone mass accrual in underprivileged Indian premenarcheal girls.Methods: A double blind, matched pair, cluster randomization study was carried out in 200 premenarcheal girls (8–12 years) from three public schools. The participants were randomized into two clusters and were allocated to receive either vitamin D (Group A): 30 000 IU oral cholecalciferol eve...